What Researchers Did
Researchers conducted an evidence-based review of literature from 1980-2008 to assess non-pharmacological interventions for acute acquired brain injury.
What They Found
The review assessed seven non-pharmacological interventions, including five non-invasive (head posture, body rotation, hyperventilation, hypothermia, hyperbaric oxygen) and two invasive (CSF drainage, decompressive craniectomy). Strong evidence was found for only four of these seven interventions (decompressive craniectomy, CSF drainage, hypothermia, and hyperbaric oxygen), and only for specific aspects of their application.
Canadian Relevance
This evidence-based review, conducted with Canadian involvement, directly informs clinical practice guidelines for managing acute acquired brain injury in Canadian healthcare settings.
Study Limitations
A significant limitation was the overall paucity of strong evidence for many non-pharmacological interventions, with robust findings available for only specific components of four out of seven assessed treatments.