Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms | Canada Hyperbarics Skip to main content
RCT Undersea Hyperb Med 2019

Adverse events and blinding in two randomized trials of hyperbaric oxygen for persistent post-concussive symptoms

Churchill S, Deru K, Weaver L, Wilson S, Hebert D, Miller R, et al. — Undersea Hyperb Med, 2019

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers reported safety monitoring data from two randomized double-blind HBOT trials involving 143 military personnel with post-concussive symptoms, receiving either HBOT at 1.5 ATA or sham at 1.2 ATA across 4,245 total chamber sessions.

What They Found

Adverse events were rare: 1.1% of sessions in HOPPS and 2.2% in BIMA. Minor barotrauma (ear pressure effects) was the most common complaint. No serious chamber-related adverse events occurred. The sham control successfully preserved blinding throughout both trials.

What This Means for Canadian Patients

HBOT at 1.5 ATA is very well tolerated. The extremely low serious adverse event rate across thousands of sessions is reassuring for Canadian patients and clinicians considering HBOT for concussion-related symptoms.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The study population was entirely US military personnel; adverse event rates may differ in civilian populations with different health profiles or treatment protocols.

Was this summary helpful?

Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 31394602
Year Published 2019
Journal Undersea Hyperb Med
MeSH Terms Adult; Barotrauma; Brain Concussion; Double-Blind Method; Earache; Female; Headache; Humans; Hyperbaric Oxygenation; Male; Military Personnel; Pilot Projects; Post-Concussion Syndrome; Random Allocation; Safety

Cite This Study

Share
Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.