What Researchers Did
Researchers reviewed the current understanding of high altitude headache, including its definition, potential complications, suspected pathophysiology, and available preventive and treatment strategies.
What They Found
High altitude headache is defined as a headache appearing within 24 hours after ascent to 2,500 m or higher, which can occur in isolation or as part of acute mountain sickness. If symptoms are ignored, more serious conditions like high altitude cerebral oedema or death may ensue. The pathophysiology is speculated to involve hypoxemia-induced intracranial vasodilation and subsequent cerebral oedema, with various preventive measures and pharmacological interventions available.
Canadian Relevance
This study does not have a direct Canadian connection.
Study Limitations
A limitation of this review is that it synthesizes existing knowledge, reflecting the current lack of a definitive understanding of the underlying pathophysiologic mechanism of high altitude headache.