Study Pak J Med Sci 2021

An observation of the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen in treating acute spinal cord injury

Li H, Cui J, Fan J, Tong J — Pak J Med Sci, 2021

View Original on PubMed PMID 33679906

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers studied 80 patients with acute spinal cord injury from thoracolumbar fractures, comparing conventional postoperative care to a combination of riluzole, mannitol, and hyperbaric oxygen therapy.

What They Found

Both groups showed improved motor and sensory function after treatment. However, the group receiving riluzole, mannitol, and hyperbaric oxygen showed significantly greater improvements in motor and sensory function compared to the control group (p<0.05). This combined therapy also led to significantly lower levels of inflammatory markers (IL-6) and growth factors (BDNF, NFGF) in the experimental group (p<0.05).

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This study was conducted at a single hospital with a relatively small number of patients and a short follow-up period of four weeks.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Study
Category	Neurological
Source	Pubmed
PubMed ID	33679906
Year Published	2021
Journal	Pak J Med Sci

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Last reviewed: April 17, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology