RCT Minerva anestesiologica 1995

Assessment of lipid peroxidation in hyperbaric oxygen therapy: protective role of N-acetylcysteine.

Pelaia P, Rocco M, De Blasi RA, Spadetta G, Alampi D, Araimo FS, et al. — Minerva anestesiologica, 1995

View Original on PubMed PMID 7675271

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomised study on 17 patients to assess lipid peroxidation during hyperbaric oxygen therapy (HBO) and the protective role of N-acetylcysteine (NAC).

What They Found

They found that hyperbaric oxygen therapy (HBO) significantly increased lipid peroxidation, as measured by TBARS, in patients receiving HBO alone (p < 0.01). However, patients receiving N-acetylcysteine (NAC) in addition to HBO showed protection against this radicalic stress, with a significant difference in TBARS values between groups at the beginning of the 20th session (p < 0.01).

Canadian Relevance

This study has no direct Canadian connection as it was conducted in Italy.

Study Limitations

A key limitation of this study is its very small sample size of 17 patients, which may limit the generalizability of the findings.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	7675271
Year Published	1995
Journal	Minerva anestesiologica
MeSH Terms	Acetylcysteine; Humans; Hyperbaric Oxygenation; Lipid Peroxidation

Related Research

PLoS ONE | 2013 RCT

Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.

Efrati S, Fishlev G, Bechor Y, et al.

J Neurotrauma | 2018 Systematic Review

Hyperbaric oxygen therapy in the treatment of acute severe traumatic brain injury: a systematic review

Daly S, Thorpe M, Rockswold S, et al.

J Neurotrauma | 2012 Pilot Study

A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and PTSD

Harch PG, Andrews SR, Fogarty EF, et al.

Scientific Reports | 2022 RCT

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.

Hadanny A, Zilberman-Itskovich S, Catalogna M, et al.

PLoS ONE | 2013 RCT

Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury — randomized prospective trial

Boussi-Gross R, Golan H, Fishlev G, et al.

See all Neurological research

View on PubMed Back to Research Library

Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology