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RCT Chinese medical journal 2011

Autologous bone marrow stem cell transplantation for the treatment of type 2 diabetes mellitus.

Wang L, Zhao S, Mao H, Zhou L, Wang ZJ, Wang HX — Chinese medical journal, 2011

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effect of autologous bone marrow stem cell transplantation combined with hyperbaric oxygen treatment on 31 patients with type 2 diabetes mellitus.

What They Found

Mean HbA1c values significantly decreased by over 1.5% (from 8.7% to 7.1%) within 30 days after transplantation. This reduction then stabilized, fluctuating within 0.5% until 24 months. C-peptide levels also significantly increased at 90 days post-therapy (P < 0.0001) compared to baseline.

What This Means for Canadian Patients

This experimental treatment for type 2 diabetes mellitus showed initial improvements in blood sugar control and pancreatic function. While promising, this is not a standard therapy and requires further research before it could be considered for Canadian patients.

Canadian Relevance

This study has no direct Canadian connection as it was conducted in China.

Study Limitations

Limitations include the small sample size of 31 patients and the observation that initial improvements in HbA1c and C-peptide were not continuously sustained over the entire follow-up.

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Study Details

Study Type RCT
Category Aging & Longevity
Source Pubmed
PubMed ID 22340214
Year Published 2011
Journal Chinese medical journal
MeSH Terms Adult; Bone Marrow Cells; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Male; Middle Aged; Prospective Studies; Stem Cell Transplantation

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.