Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce.

What Researchers Did

Researchers retrospectively evaluated cerebral perfusion in 25 secondary progressive multiple sclerosis patients, comparing brain perfusion before and after hyperbaric oxygen therapy in a subset of 16 patients.

What They Found

Of 25 secondary progressive multiple sclerosis patients, 23 (92%) showed abnormal brain perfusion. The study found a significant association between the severity of perfusion impairment and both disease duration and EDSS scores (P < 0.05). Additionally, there was a significant improvement in brain perfusion scans following hyperbaric oxygen therapy (P < 0.05).

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

Key limitations include the retrospective design and the small sample size of only 25 patients, which limits the generalizability of the findings.