What Researchers Did
This review synthesized current understanding of cellular senescence's role in brain aging and age-related cognitive decline.
What They Found
Cellular senescence is a key factor in neurodegenerative diseases and may accelerate brain aging and cognitive decline in specific patient populations such as cancer survivors and those with chronic kidney disease. The review also discussed limitations of current senotherapies like senolytics and senomorphics, while highlighting emerging evidence for hyperbaric oxygen therapy and immune-directed therapies in reducing senescent cell burden.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
As a review, this study synthesizes existing literature and does not present new experimental data or clinical trial results.