Pilot Study Diving and hyperbaric medicine 2015

Cerebrospinal fluid markers of central nervous system injury in decompression illness - a case-controlled pilot study.

Shahim P, Arnell P, Kvarnström A, Rosén A, Bremell D, Hagberg L, et al. — Diving and hyperbaric medicine, 2015

View Original on PubMed PMID 26687311

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a pilot case-controlled study comparing cerebrospinal fluid biomarkers in seven male divers with decompression sickness and seven age-matched controls.

What They Found

No significant differences were found in CSF markers for neuronal injury (total tau, neurofilament light), astroglial injury, or amyloid-beta metabolism between the seven DCS patients and seven controls. However, the single diver with central nervous system symptoms exhibited the highest levels of CSF total tau, Aβ38, Aβ40, and Aβ42.

Canadian Relevance

This pilot study was not conducted in Canada and has no direct Canadian connection.

Study Limitations

A significant limitation of this pilot study is its very small sample size of only seven DCS patients and seven controls.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Pilot Study
Category	Neurological
Source	Pubmed
PubMed ID	26687311
Year Published	2015
Journal	Diving and hyperbaric medicine
MeSH Terms	Adult; Amyloid beta-Peptides; Astrocytes; Biomarkers; Case-Control Studies; Central Nervous System; Decompression; Decompression Sickness; Diving; Humans; Hyperbaric Oxygenation; Interleukin-6; Interleukin-8; Male; Neurocalcin

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology