Clinical Study The Journal of clinical psychiatry 1984

Chemotherapy of cognitive disorders in geriatric subjects.

Goodnick P, Gershon S — The Journal of clinical psychiatry, 1984

View Original on PubMed PMID 6327657

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed various pharmacological treatment techniques for cognitive disorders in geriatric subjects, focusing on neurochemical changes associated with aging and senile dementia.

What They Found

The study found that neurochemical changes like lower choline acetyltransferase and higher monoamine oxidase are more pronounced in senile dementia, Alzheimer's type. While most treatments have been unsuccessful, vasodilators like cyclandelate and hydergine showed potential value in some patients, and postsynaptic treatments such as physostigmine offered future hope.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A significant limitation of this review is its publication date of 1984, meaning many discussed treatments and understandings have since been superseded by newer research.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	6327657
Year Published	1984
Journal	The Journal of clinical psychiatry
MeSH Terms	Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Cognition Disorders; Cyclandelate; Electroencephalography; Humans; Memory; Methylphenidate; Pentylenetetrazole; Phosphatidylcholines

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology