Clinical examination of 3 patients with delayed neuropsychiatric encephalopathy induced by carbon monoxide poisoning, who recovered from severe neurocognitive impairment by repetitive hyperbaric oxygen therapy

What Researchers Did

Researchers examined three male patients around 50 years old who developed delayed brain complications after carbon monoxide poisoning and received hyperbaric oxygen therapy.

What They Found

Delayed neuropsychiatric encephalopathy appeared about 25 days after acute carbon monoxide poisoning, and hyperbaric oxygen therapy (HBOT) was started within 8 days of this onset. Although two of the patients initially worsened, they showed significant improvement in their brain function after 30 sessions of HBOT. The study also found that changes in brain wave tests (EEG) and neurocognitive tests closely matched the patients' recovery.

Canadian Relevance

Carbon monoxide poisoning is a Health Canada-recognised indication for hyperbaric oxygen therapy. No direct Canadian connection identified for the study itself.

Study Limitations

This was a small case report involving only three patients, which means the findings cannot be widely applied to all patients with similar conditions.