Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies. | Canada Hyperbarics Skip to main content
Meta-Analysis Crit Care 2023

Early hyperbaric oxygen therapy is associated with favorable outcome in patients with iatrogenic cerebral arterial gas embolism: systematic review and individual patient data meta-analysis of observational studies.

Fakkert RA, Groen JM, van Hulst RA, et al. — Crit Care, 2023

View Original on PubMed PMID 37434172
Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a group-level and individual patient-level meta-analysis of observational studies to assess the relationship between time to hyperbaric oxygen therapy (HBOT) and outcome in patients with iatrogenic cerebral arterial gas embolism (CAGE).

What They Found

The group-level meta-analysis of 10 studies (263 patients) showed that patients with favorable outcomes received HBOT 2.4 hours earlier (95% CI 0.6-9.7) than those with unfavorable outcomes. An individual patient-level analysis of 8 studies (126 patients) further revealed a significant relationship (p=0.013) where the probability of a favorable outcome decreased from approximately 65% with immediate HBOT to 30% with delayed treatment.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study's limitations include its reliance on observational studies, which may introduce heterogeneity and confounding factors.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Meta-Analysis
Category Neurological
Source Pubmed
PubMed ID 37434172
Year Published 2023
Journal Crit Care

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: June 8, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology