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RCT Adv Wound Care (New Rochelle) 2021

Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury

Lu Y, Zhou X, Cheng J, Ma Q, Adv Wound Care (New Rochelle), 2021

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers tested whether adding hyperbaric oxygen therapy to rehabilitation training, at different intensities, helped patients recover better after moderate-to-severe traumatic brain injury.

What They Found

This multicenter, randomized, stratified case-controlled trial of 158 patients with moderate-severe traumatic brain injury found that scores on four function tests (FIM, FMA, MBI, and MMSE) improved significantly across all four treatment groups after 1, 2, and 3 months of training (p less than 0.01). Improvement was especially remarkable in the group that received twice-daily intensified rehabilitation training combined with hyperbaric oxygen therapy (p less than 0.01). The abstract does not report how the other three groups compared with each other.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The trial did not report exact p-values beyond "less than 0.01," and did not specify how the four groups differed from one another in size or baseline severity, limiting how precisely the results can be interpreted.

This plain-language summary was generated with AI assistance from the study's abstract; it has not been individually reviewed by a clinician. Always consult the source study and a qualified healthcare professional. See our editorial policy.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 34546088
Year Published 2021
Journal Adv Wound Care (New Rochelle)
MeSH Terms Activities of Daily Living; Adult; Aged; Aged, 80 and over; Brain Injuries, Traumatic; Case-Control Studies; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Prognosis; Prospective Studies; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last updated: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology