Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury | Canada Hyperbarics Skip to main content
RCT Adv Wound Care (New Rochelle) 2021

Early Intensified Rehabilitation Training with Hyperbaric Oxygen Therapy Improves Functional Disorders and Prognosis of Patients with Traumatic Brain Injury

Lu Y, Zhou X, Cheng J, Ma Q — Adv Wound Care (New Rochelle), 2021

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Chinese researchers ran a multicenter randomised trial with 158 moderate-to-severe traumatic brain injury patients, testing four combinations of rehabilitation intensity and HBOT over 3 months.

What They Found

All four groups improved in cognitive, daily living, and motor function scores. The group receiving twice-daily intensive rehabilitation combined with HBOT showed significantly greater improvement at 1, 2, and 3 months (p less than 0.01). Standard once-daily rehab with HBOT also outperformed rehab without HBOT.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The open-label multicenter design makes blinding difficult, and the study population was drawn entirely from Chinese hospitals, limiting direct applicability to Canadian TBI demographics.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 34546088
Year Published 2021
Journal Adv Wound Care (New Rochelle)
MeSH Terms Activities of Daily Living; Adult; Aged; Aged, 80 and over; Brain Injuries, Traumatic; Case-Control Studies; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Prognosis; Prospective Studies; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology