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Pilot Study Undersea Hyperb Med 2025

EEG-based brain biomarker supports hyperbaric oxygen therapy for acute concussions

Denham D, Denham M — Undersea Hyperb Med, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers tested whether HBOT could improve concussion recovery in youth athletes using an AI-based brain wave measurement tool (EEG biomarker) to objectively track improvement.

What They Found

Eleven student-athletes with confirmed concussions had a median EEG brain score of 18 (out of 100) at baseline, well below the 70-point threshold considered normal. After a median of 3 HBOT sessions at 1.5–2.0 atmospheres, the median score rose to 85, and the median final follow-up score (2–22 days later) was also 85. No adverse events occurred.

Canadian Relevance

No direct Canadian connection identified. Concussion is not an OHIP-covered indication for HBOT in Ontario.

Study Limitations

This was a pilot study of only 11 patients with no control group, so it cannot rule out that athletes would have recovered at this rate without HBOT.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Pilot Study
Category Neurological
Source Pubmed
PubMed ID 40819349
Year Published 2025
Journal Undersea Hyperb Med
MeSH Terms Humans; Hyperbaric Oxygenation; Brain Concussion; Male; Electroencephalography; Adolescent; Female; Pilot Projects; Biomarkers; Athletic Injuries; Child; Acute Disease

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology