Prospective Study PLoS One 2021

Effect of ethanol in carbon monoxide poisoning and delayed neurologic sequelae: A prospective observational study

Choi S, Han S, Nah S, Lee Y, Cho Y, Lim H, et al. — PLoS One, 2021

View Original on PubMed PMID 33428685

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This prospective observational study investigated whether ethanol has a neuroprotective effect against delayed neurologic sequelae (DNS) in 171 patients with carbon monoxide (CO) poisoning.

What They Found

Out of 171 patients, 28 (16.37%) developed DNS. Patients without DNS had higher initial Glasgow Coma Scale (GCS) scores (15 vs 10, p = 0.002) and higher ethanol levels (11.01 ± 17.58 mg/dL vs 1.49 ± 2.63 mg/dL, p < 0.001). Multivariate analysis showed that higher GCS scores (OR 0.770, p < 0.001) and higher ethanol levels (OR 0.882, p < 0.030) were associated with a lower incidence of DNS.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada or by Canadian researchers.

Study Limitations

As an observational study, this research cannot establish a causal relationship between ethanol and neuroprotection, and potential confounding factors were not fully explored.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Prospective Study
Category	Neurological
Source	Pubmed
PubMed ID	33428685
Year Published	2021
Journal	PLoS One
MeSH Terms	Adult; Carbon Monoxide Poisoning; Central Nervous System Depressants; Emergency Service, Hospital; Ethanol; Female; Humans; Hyperbaric Oxygenation; Male; Mental Disorders; Prospective Studies; Risk Factors; Time Factors

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology