Cohort Study BMJ Open 2018

Effect of hyperbaric oxygen therapy on chronic neurocognitive deficits of post-traumatic brain injury patients: retrospective analysis

Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S — BMJ Open, 2018

View Original on PubMed PMID 30269074

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers retrospectively analyzed 154 patients with chronic cognitive deficits from traumatic brain injury (TBI) of all severities who underwent HBOT and pre- and post-treatment cognitive testing and brain SPECT imaging.

What They Found

All cognitive domains showed significant improvement after HBOT, with a mean global cognitive score improvement of 4.6 points (p < 0.00001). Memory and attention showed the most dramatic gains. Brain SPECT imaging showed increased metabolic activity in the prefrontal, temporal, and anterior cingulate regions.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This was a retrospective cohort study with no control group; the improvement may partly reflect natural recovery over time, and selection bias is possible in patients who chose to pursue HBOT.

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Study Details

Study Type	Cohort Study
Category	Neurological
Source	Pubmed
PubMed ID	30269074
Year Published	2018
Journal	BMJ Open
MeSH Terms	Adult; Brain; Brain Injuries, Traumatic; Cognition Disorders; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Neuropsychological Tests; Retrospective Studies; Tomography, Emission-Computed, Single-Photon

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology