RCT Neuroscience letters 2019

Effect of hyperbaric oxygen therapy on HMGB1/NF-κB expression and prognosis of acute spinal cord injury: A randomized clinical trial.

Sun L, Zhao L, Li P, Liu X, Liang F, Jiang Y, et al. — Neuroscience letters, 2019

View Original on PubMed PMID 30391318

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomised clinical trial to evaluate the effect of hyperbaric oxygen therapy on HMGB1/NF-κB expression and neurological outcomes in 79 patients with acute spinal cord injury.

What They Found

Compared to conventional treatment, hyperbaric oxygen therapy significantly down-regulated HMGB1 and NF-κB expression from day 3 to day 30 (p < 0.05). It also decreased F-wave chronodispersion at days 10 and 30 (p < 0.01), and improved ASIA and Frankel Grade motor/pain scores by day 30 (p < 0.01).

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada or with Canadian participants.

Study Limitations

The study's relatively short follow-up period of 30 days may limit the assessment of long-term neurological recovery and sustained effects of hyperbaric oxygen therapy.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	30391318
Year Published	2019
Journal	Neuroscience letters
MeSH Terms	Female; HMGB1 Protein; Humans; Hyperbaric Oxygenation; Male; Middle Aged; NF-kappa B; Spinal Cord Injuries; Tibial Nerve; Treatment Outcome

Related Research

PLoS ONE | 2013 RCT

Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.

Efrati S, Fishlev G, Bechor Y, et al.

J Neurotrauma | 2018 Systematic Review

Hyperbaric oxygen therapy in the treatment of acute severe traumatic brain injury: a systematic review

Daly S, Thorpe M, Rockswold S, et al.

J Neurotrauma | 2012 Pilot Study

A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and PTSD

Harch PG, Andrews SR, Fogarty EF, et al.

Scientific Reports | 2022 RCT

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.

Hadanny A, Zilberman-Itskovich S, Catalogna M, et al.

PLoS ONE | 2013 RCT

Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury — randomized prospective trial

Boussi-Gross R, Golan H, Fishlev G, et al.

See all Neurological research

View on PubMed Back to Research Library

Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology