Retrospective Study Frontiers in neurology 2025

Effect of hyperbaric oxygen therapy on peripheral blood inflammatory markers in patients with neuromyelitis optica spectrum disorder: a retrospective cohort study.

Pan L, Mo Y, Wei Y, Luo S, Wu Y — Frontiers in neurology, 2025

View Original on PubMed PMID 41312352

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a retrospective cohort study involving 36 patients with neuromyelitis optica spectrum disorder (NMOSD) to evaluate the effect of hyperbaric oxygen therapy (HBOT) on peripheral inflammatory markers.

What They Found

After a median of 12 HBOT sessions, the HBOT group showed a 31.78% increase in lymphocyte count (Δ = +0.41 × 10^9/L, p < 0.001) compared to the control group. This group also experienced significant reductions in neutrophil-to-lymphocyte ratio (NLR) by 26.92% (Δ = -0.63, p < 0.001) and platelet-to-lymphocyte ratio (PLR) by 20.31% (Δ = -25.56, p < 0.001).

Canadian Relevance

This study does not have a direct Canadian connection.

Study Limitations

The retrospective nature of this study and its small sample size limit the generalizability of the findings, and larger prospective studies are needed to confirm long-term efficacy.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Retrospective Study
Category	Neurological
Source	Pubmed
PubMed ID	41312352
Year Published	2025
Journal	Frontiers in neurology

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology