Clinical Study Stroke 1998

Effects of high atmospheric pressure and oxygen on middle cerebral blood flow velocity in humans measured by transcranial Doppler.

Omae T, Ibayashi S, Kusuda K, Nakamura H, Yagi H, Fujishima M — Stroke, 1998

View Original on PubMed PMID 9445335

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers measured middle cerebral arterial blood flow velocity (MCV) and transcutaneous gas in healthy volunteers under various atmospheric pressure and oxygen conditions using transcranial Doppler.

What They Found

In eight volunteers, MCV decreased and transcutaneous oxygen (tcPO2) increased significantly under 1 atmosphere absolute (ATA) oxygen, 2 ATA air, and 2 ATA oxygen compared to 1 ATA air. A second group of eight volunteers showed no difference in MCV or tcPO2 between 4 ATA air and 1 ATA plus oxygen, indicating that environmental pressure did not influence MCV when tcPO2 was kept similar.

Canadian Relevance

There is no direct Canadian connection mentioned in this study.

Study Limitations

The study was conducted on a small number of healthy volunteers, limiting the generalizability of findings to patient populations or diverse demographics.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	9445335
Year Published	1998
Journal	Stroke
MeSH Terms	Adult; Analysis of Variance; Atmospheric Pressure; Blood Flow Velocity; Blood Gas Monitoring, Transcutaneous; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Environmental Exposure; Female; Humans; Hyperbaric Oxygenation; Hyperoxia; Inhalation; Male

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology