RCT Journal of neurosurgery 2001

Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients.

Rockswold SB, Rockswold GL, Vargo JM, Erickson CA, Sutton RL, Bergman TA, et al. — Journal of neurosurgery, 2001

View Original on PubMed PMID 11235943

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effects of hyperbaric oxygenation (HBO) therapy on cerebral blood flow, metabolism, and intracranial pressure in 37 severely brain-injured patients, administering 100% oxygen daily.

What They Found

In patients with reduced cerebral blood flow (CBF) before HBO, both CBF and cerebral metabolic rate of oxygen (CMRO2) increased 1 and 6 hours after treatment (p < 0.05). For those with normal CBF, both parameters increased at 1 hour (p < 0.05) but decreased by 6 hours. Patients with raised CBF experienced reduced CBF 1 and 6 hours post-HBO (p < 0.05) with unchanged CMRO2.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada or by Canadian researchers.

Study Limitations

The study involved a relatively small sample size of 37 patients, and the abstract provided was incomplete, limiting a full understanding of all reported limitations.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	11235943
Year Published	2001
Journal	Journal of neurosurgery
MeSH Terms	Adolescent; Adult; Aged; Aged, 80 and over; Blood Gas Analysis; Blood Pressure; Brain; Brain Injuries; Cerebral Arteries; Cerebral Veins; Cerebral Ventricles; Cerebrovascular Circulation; Child; Energy Metabolism; Female

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology