RCT Med Sci Monit 2017

Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning

Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, et al. — Med Sci Monit, 2017

View Original on PubMed PMID 28352069

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a randomised controlled trial to evaluate the efficacy of N-Butylphthalide combined with hyperbaric oxygen therapy (HBO) versus HBO alone for cognitive dysfunction in 184 patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).

What They Found

After eight weeks, the experimental group (N-Butylphthalide + HBO) demonstrated a significantly higher total remission rate of 47.9% compared to the control group (HBO alone) at 33.3%. Additionally, significantly more patients in the experimental group achieved MMSE scores of 24-30, indicating improved cognitive function, and showed better neurological function with lower NIHSS scores.

Canadian Relevance

This study was not conducted in Canada and does not have a direct Canadian connection.

Study Limitations

A limitation not explicitly detailed in the abstract could be the relatively short eight-week follow-up period, which may not capture long-term outcomes.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	28352069
Year Published	2017
Journal	Med Sci Monit
MeSH Terms	Acute Disease; Benzofurans; Brain Diseases; Carbon Monoxide Poisoning; Cognitive Dysfunction; Demography; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Neuropsychological Tests; Remission Induction; Treatment Outcome

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology