Clinical Trial Mult Scler Relat Disord 2020

Engagement of people with multiple sclerosis to enhance research into the physiological effect of hyperbaric oxygen therapy

Moore L, Eggleton P, Smerdon G, Newcombe J, Holley J, Gutowski N, et al. — Mult Scler Relat Disord, 2020

View Original on PubMed PMID 32442882

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers engaged three people with multiple sclerosis (MS) and an MS Centre manager to inform a laboratory study investigating the physiological effects of oxygen therapy on microvascular brain endothelial cells.

What They Found

They found that MS patients often use oxygen therapy at later stages, typically at 100% O2 at 1.5 atmosphere absolute (1140 mmHg absolute) for 60 minutes. In a lab setting, human brain endothelial cells exposed in vitro to 152 mmHg O2 for 60 minutes showed a significant reduction in ICAM-1 (CD54), a marker implicated in inflammatory cell margination across the blood-brain barrier.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The study's primary physiological findings were from an in vitro lab experiment, and the patient involvement group was very small.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Trial
Category	Neurological
Source	Pubmed
PubMed ID	32442882
Year Published	2020
Journal	Mult Scler Relat Disord
MeSH Terms	Brain; Endothelial Cells; Humans; Hyperbaric Oxygenation; Multiple Sclerosis; Oxygen

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology