Etiology, clinical aspects and therapy of altitude sickness.

What Researchers Did

Researchers reviewed recent experimental and clinical findings on the pathophysiology and acute therapy of high-altitude sickness.

What They Found

They found that azetazolamide's clinical effectiveness and improvement of body gas exchange are largely proven. Dexamethasone significantly reduced symptoms, particularly for cerebral high-altitude oedema, compared to placebo, with effects lasting 12 hours. Nifedipine improved oxygenation and reduced pulmonary-arterial pressure in radiologically proven high-altitude oedema.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The abstract does not detail the specific methodologies or limitations of the individual studies it synthesizes.