Review Neurocritical care 2013

Factors associated with favorable response to hyperbaric oxygen therapy among patients presenting with iatrogenic cerebral arterial gas embolism.

Tekle WG, Adkinson CD, Chaudhry SA, Jadhav V, Hassan AE, Rodriguez GJ, et al. — Neurocritical care, 2013

View Original on PubMed PMID 22396189

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed medical records and neuroimaging of 36 consecutive patients with iatrogenic cerebral arterial gas embolism (CAGE) treated with hyperbaric oxygen therapy (HBO2) over 22 years to identify factors associated with a favorable outcome.

What They Found

A total of 26 (72%) of the 36 patients experienced a favorable outcome. Patients with favorable outcomes were younger (mean age 44.7 vs 58.1 years), and receiving HBO2 within 6 hours of the event was an independent predictor of a positive response. Conversely, the presence of infarct or oedema on pre-treatment imaging negatively predicted a favorable outcome.

Canadian Relevance

This study does not have a direct Canadian connection as it was conducted at a state referral hyperbaric facility outside of Canada.

Study Limitations

Limitations include the retrospective design, relatively small sample size of 36 patients, and its single-center nature over a long period.

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Study Details

Study Type	Review
Category	Neurological
Source	Pubmed
PubMed ID	22396189
Year Published	2013
Journal	Neurocritical care
MeSH Terms	Adult; Age Factors; Aged; Aged, 80 and over; Brain Edema; Brain Infarction; Cerebral Arterial Diseases; Embolism, Air; Female; Humans; Hyperbaric Oxygenation; Iatrogenic Disease; Male; Middle Aged; Time Factors

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology