RCT Medicine 2023

HBOT has a better cognitive outcome than NBH for patients with mild traumatic brain injury: A randomized controlled clinical trial.

Liu Z, Wang X, Wu Z, Yin G, Chu H, Zhao P — Medicine, 2023

View Original on PubMed PMID 37713814

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomised controlled trial comparing normobaric hyperoxia (NBH) and hyperbaric oxygen therapy (HBOT) with a control group in patients with mild traumatic brain injury (TBI).

What They Found

Both NBH and HBOT significantly improved MoCA and MMSE scores and decreased levels of S100β, NSE, GFAP, HIF-1α, MDA, and rSO2 compared to the control group. Patients receiving HBOT demonstrated even higher MoCA and MMSE scores and lower levels of these biomarkers than those in the NBH group.

Canadian Relevance

This study was not conducted in Canada and has no direct Canadian connection.

Study Limitations

A limitation of this study is that it was conducted at a single center and had a relatively short follow-up period of 30 days.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	37713814
Year Published	2023
Journal	Medicine
MeSH Terms	Humans; Brain Concussion; Hyperbaric Oxygenation; Hyperoxia; Prospective Studies; S100 Calcium Binding Protein beta Subunit; Cognition

Related Research

PLoS ONE | 2013 RCT

Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.

Efrati S, Fishlev G, Bechor Y, et al.

J Neurotrauma | 2018 Systematic Review

Hyperbaric oxygen therapy in the treatment of acute severe traumatic brain injury: a systematic review

Daly S, Thorpe M, Rockswold S, et al.

J Neurotrauma | 2012 Pilot Study

A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and PTSD

Harch PG, Andrews SR, Fogarty EF, et al.

Scientific Reports | 2022 RCT

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.

Hadanny A, Zilberman-Itskovich S, Catalogna M, et al.

PLoS ONE | 2013 RCT

Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury — randomized prospective trial

Boussi-Gross R, Golan H, Fishlev G, et al.

See all Neurological research

View on PubMed Back to Research Library

Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology