Clinical Study BioMed research international 2018

HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure.

Wu HH, Niu KC, Lin CH, Lin HJ, Chang CP, Wang CT — BioMed research international, 2018

View Original on PubMed PMID 30515398

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated whether hyperbaric oxygen therapy (HBO) mediated by HSP-70 could reduce brain and pulmonary oedema and cognitive deficits in rats exposed to simulated high altitude.

What They Found

The study found that hyperbaric oxygen therapy significantly reduced brain and pulmonary oedema in rats exposed to simulated high altitude. It also demonstrated an improvement in cognitive deficits in the treated group compared to controls.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A primary limitation of this study is that its findings are based on a rat model, which may not directly translate to human physiology.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	30515398
Year Published	2018
Journal	BioMed research international
MeSH Terms	Altitude; Altitude Sickness; Animals; Antibodies; Body Weight; Brain; Cognitive Dysfunction; Disease Models, Animal; Encephalitis; HSP70 Heat-Shock Proteins; Hippocampus; Humans; Hyperbaric Oxygenation; Lung; Oxidative Stress

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology