HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure. | Canada Hyperbarics Skip to main content
Clinical Study BioMed research international 2018

HSP-70-Mediated Hyperbaric Oxygen Reduces Brain and Pulmonary Edema and Cognitive Deficits in Rats in a Simulated High-Altitude Exposure.

Wu HH, Niu KC, Lin CH, Lin HJ, Chang CP, Wang CT — BioMed research international, 2018

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated whether hyperbaric oxygen therapy (HBO) mediated by HSP-70 could reduce brain and pulmonary edema and cognitive deficits in rats exposed to simulated high altitude.

What They Found

The study found that hyperbaric oxygen therapy significantly reduced brain and pulmonary edema in rats exposed to simulated high altitude. It also demonstrated an improvement in cognitive deficits in the treated group compared to controls.

What This Means for Canadian Patients

While this study was conducted in rats, its findings suggest a potential therapeutic role for hyperbaric oxygen therapy in managing high-altitude sickness. This could eventually lead to new strategies for Canadian patients experiencing severe symptoms like brain and pulmonary edema when exposed to high altitudes.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

A primary limitation of this study is that its findings are based on a rat model, which may not directly translate to human physiology.

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Study Details

Study Type Clinical Study
Category Neurological
Source Pubmed
PubMed ID 30515398
Year Published 2018
Journal BioMed research international
MeSH Terms Altitude; Altitude Sickness; Animals; Antibodies; Body Weight; Brain; Cognitive Dysfunction; Disease Models, Animal; Encephalitis; HSP70 Heat-Shock Proteins; Hippocampus; Humans; Hyperbaric Oxygenation; Lung; Oxidative Stress

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.