Prospective Study Neurologia medico-chirurgica 2006

Hyperbaric oxygen combined with intravenous edaravone for treatment of acute embolic stroke: a pilot clinical trial.

Imai K, Mori T, Izumoto H, Takabatake N, Kunieda T, Watanabe M — Neurologia medico-chirurgica, 2006

View Original on PubMed PMID 16936457

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers prospectively investigated the efficacy of hyperbaric oxygen therapy combined with intravenous edaravone administration in patients with acute embolic stroke, comparing it to conventional treatment.

What They Found

At 90 days, 6 out of 19 patients (31.6%) in the hyperbaric oxygen and edaravone group achieved a favorable outcome, compared to only 1 out of 19 patients (5.3%) in the control group (p < 0.05). However, there was no significant difference in National Institutes of Health Stroke Scale scores between the two groups at 7 days.

Canadian Relevance

This study was conducted in Japan and has no direct Canadian connection.

Study Limitations

Key limitations include the small sample size of this pilot study and its single-center design.

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Study Details

Study Type	Prospective Study
Category	Neurological
Source	Pubmed
PubMed ID	16936457
Year Published	2006
Journal	Neurologia medico-chirurgica
MeSH Terms	Acute Disease; Aged; Antipyrine; Combined Modality Therapy; Edaravone; Emergency Medical Services; Female; Free Radical Scavengers; Humans; Hyperbaric Oxygenation; Intracranial Embolism; Male; Neuroprotective Agents; Pilot Projects; Severity of Illness Index

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology