RCT Annals of neurology 2014

Hyperbaric oxygen for blast-related postconcussion syndrome: three-month outcomes.

Cifu DX, Walker WC, West SL, Hart BB, Franke LM, Sima A, et al. — Annals of neurology, 2014

View Original on PubMed PMID 24255008

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a randomised, double-blind, sham-controlled study with 61 male Marines to evaluate the effects of hyperbaric oxygen at two dosing levels on blast-related postconcussion syndrome.

What They Found

The study found no significant interaction between time and intervention group for improvement on the Rivermead Post-Concussion Questionnaire-16 (RPQ-16). There was also no evidence of efficacy for any subgroup or on any functional, cognitive, or psychomotor secondary outcome measures among the 61 male Marines who received 40 hyperbaric chamber compressions.

Canadian Relevance

This study was conducted in the United States with US military personnel and has no direct Canadian connection.

Study Limitations

The study's findings are limited to male military personnel with blast-related postconcussion syndrome and may not generalize to other populations or causes of PCS.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	24255008
Year Published	2014
Journal	Annals of neurology
MeSH Terms	Adult; Analysis of Variance; Brain Injuries; Double-Blind Method; Follow-Up Studies; Humans; Hyperbaric Oxygenation; Male; Neuropsychological Tests; Post-Concussion Syndrome; Trauma Severity Indices; Treatment Outcome; Young Adult

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology