Systematic Review Undersea Hyperb Med 2019

Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies

Hart B, Weaver L, Gupta A, Wilson S, Vijayarangan A, Deru K, et al. — Undersea Hyperb Med, 2019

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review and pooled analysis of four US Department of Defense clinical trials (254 participants) plus three additional published studies (135 participants) testing HBOT for persistent post-concussive symptoms and PTSD after mild traumatic brain injury.

What They Found

Pooled analysis showed a trend favoring HBOT for post-concussive symptoms and PTSD that did not reach statistical significance, but demonstrated a statistically significant improvement in verbal memory (p = 0.01). A dose-response pattern was observed, with higher oxygen pressure associated with greater benefit.

What This Means for Canadian Patients

Mild TBI and PTSD are significant concerns for Canadian veterans and contact sport athletes. This pooled analysis suggests HBOT may improve memory and thinking after concussion, particularly at higher pressures, supporting calls for a Canadian clinical trial targeting this population.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

Pooled analyses can mask heterogeneity between studies; the populations were primarily US military personnel, which may not represent civilian Canadian patients with concussion.

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Study Details

Study Type	Systematic Review
Category	Neurological
Source	Pubmed
PubMed ID	31394604
Year Published	2019
Journal	Undersea Hyperb Med
MeSH Terms	Adult; Brain Concussion; Checklist; Female; Humans; Hyperbaric Oxygenation; Linear Models; Male; Memory; Mental Recall; Middle Aged; Military Personnel; Neuropsychological Tests; Oxygen; Partial Pressure; Post-Concussion Syndrome; Quality of Life; Sensitivity and Specificity; Stress Disorders, Post-Traumatic; Treatment Outcome; United States; United States Department of Defense; Young Adult

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.