Systematic Review Undersea Hyperb Med 2019

Hyperbaric oxygen for mTBI-associated PCS and PTSD: Pooled analysis of results from Department of Defense and other published studies

Hart B, Weaver L, Gupta A, Wilson S, Vijayarangan A, Deru K, et al. — Undersea Hyperb Med, 2019

View Original on PubMed PMID 31394604

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review and pooled analysis of four US Department of Defense clinical trials (254 participants) plus three additional published studies (135 participants) testing HBOT for persistent post-concussive symptoms and PTSD after mild traumatic brain injury.

What They Found

Pooled analysis showed a trend favoring HBOT for post-concussive symptoms and PTSD that did not reach statistical significance, but demonstrated a statistically significant improvement in verbal memory (p = 0.01). A dose-response pattern was observed, with higher oxygen pressure associated with greater benefit.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

Pooled analyses can mask heterogeneity between studies; the populations were primarily US military personnel, which may not represent civilian Canadian patients with concussion.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Systematic Review
Category	Neurological
Source	Pubmed
PubMed ID	31394604
Year Published	2019
Journal	Undersea Hyperb Med
MeSH Terms	Adult; Brain Concussion; Checklist; Female; Humans; Hyperbaric Oxygenation; Linear Models; Male; Memory; Mental Recall; Middle Aged; Military Personnel; Neuropsychological Tests; Oxygen; Partial Pressure; Post-Concussion Syndrome; Quality of Life; Sensitivity and Specificity; Stress Disorders, Post-Traumatic; Treatment Outcome; United States; United States Department of Defense; Young Adult

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology