What Researchers Did
Researchers reviewed the current evidence regarding hyperbaric oxygen therapy and the potential addition of inert gases for treating cerebral ischaemia and traumatic brain injury.
What They Found
In experimental models, hyperbaric oxygen (HBO) demonstrated neuroprotective effects in cerebral ischaemia and traumatic brain injury by modulating oxidative stress and neuro-inflammation. However, clinical trials did not confirm neuroprotective effects for cerebral ischaemia, and while preliminary results for traumatic brain injury were encouraging, they require further confirmation. The addition of inert gases like argon or xenon, which also show experimental neuroprotective effects, may offer additional benefits for cerebral lesions.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
The review highlights that current clinical evidence for hyperbaric oxygen therapy in cerebral ischaemia is inconclusive, and further rigorous multicentric studies are needed, especially for combined therapies with inert gases.