What Researchers Did
Researchers reviewed existing literature on hyperbaric oxygen therapy (HBOT) as a potential treatment for post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI).
What They Found
Some clinical trials suggested benefits of HBOT for TBI and/or PTSD, while several other studies found no improvement compared to possibly poorly controlled sham treatments. Animal models demonstrated that HBOT could reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines, suggesting its potential in treating the secondary phase of TBI and PTSD.
Canadian Relevance
This review does not have a direct Canadian connection, focusing primarily on US military personnel and general research findings.
Study Limitations
A key limitation is the inconsistency across clinical trials, with some studies using possibly poorly controlled sham groups, making definitive conclusions challenging.