Clinical Trial Acta Neurochir Suppl 2008

Hyperbaric oxygen therapy for consciousness disturbance following head injury in subacute phase

Nakamura T, Kuroda Y, Yamashita S, Kawakita K, Kawai N, Tamiya T, et al. — Acta Neurochir Suppl, 2008

View Original on PubMed PMID 19388281

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the effect of hyperbaric oxygen (HBO) therapy on cerebral circulation and metabolism in seven head injury patients with consciousness disturbances in the subacute phase.

What They Found

In seven head injury patients, hyperbaric oxygen therapy significantly decreased both the pulsatility index (PI) and jugular venous lactate (lac-JV). No significant changes were observed in mean flow velocity (mFV) or arterio-jugular venous difference of oxygen (AJDO2).

Canadian Relevance

This study was not conducted in Canada and does not have a direct Canadian connection.

Study Limitations

A significant limitation of this study is its very small sample size of seven patients and its focus on physiological markers rather than long-term clinical outcomes.

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Study Details

Study Type	Clinical Trial
Category	Neurological
Source	Pubmed
PubMed ID	19388281
Year Published	2008
Journal	Acta Neurochir Suppl
MeSH Terms	Adult; Aged; Cerebrovascular Circulation; Child; Consciousness Disorders; Craniocerebral Trauma; Female; Glasgow Coma Scale; Humans; Hyperbaric Oxygenation; Jugular Veins; Lactic Acid; Male; Regression Analysis; Retrospective Studies; Young Adult

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Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology