Hyperbaric oxygen therapy for late onset dropped head syndrome following mantle field radiation therapy for Hodgkin lymphoma: a case report and literature review | Canada Hyperbarics Skip to main content
Case Report Diving Hyperb Med 2025

Hyperbaric oxygen therapy for late onset dropped head syndrome following mantle field radiation therapy for Hodgkin lymphoma: a case report and literature review

Rosenzweig S, Thompson S, Bennett M — Diving Hyperb Med, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Clinicians documented the first reported case of HBOT treating radiation-induced dropped head syndrome in a 59-year-old man who developed severe neck extensor weakness 34 years after mantle field radiotherapy for Hodgkin lymphoma, treating him with 60 HBOT sessions alongside physiotherapy and thiamine supplementation.

What They Found

The patient showed meaningful improvement in his ability to maintain head position and swallow after completing 60 HBOT sessions. Improvements were maintained at 3-year follow-up, providing unusually durable long-term benefit for a condition with very limited treatment options.

What This Means for Canadian Patients

Thousands of Canadians who survived Hodgkin lymphoma with older radiation techniques may develop late-onset radiation injuries decades after treatment. Radiation-induced tissue damage is an OHIP-covered indication for HBOT in Ontario, and this case adds to evidence supporting HBOT for late radiation complications beyond traditional indications.

Canadian Relevance

Delayed radiation injury is an OHIP-covered indication for HBOT in Ontario. Canadian Hodgkin lymphoma survivors treated with mantle field radiation should be aware that HBOT may be beneficial if late-onset neurological or musculoskeletal radiation complications develop.

Study Limitations

Single case report with co-interventions (physiotherapy, thiamine); the independent contribution of HBOT versus the other treatments cannot be determined.

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Study Details

Study Type Case Report
Category Radiation Injury
Source Pubmed
PubMed ID 40986924
Year Published 2025
Journal Diving Hyperb Med
MeSH Terms Humans; Male; Hyperbaric Oxygenation; Hodgkin Disease; Middle Aged; Muscle Weakness; Radiation Injuries; Neck Muscles; Syndrome; Deglutition Disorders; Dropped Head Syndrome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.