Hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity syndrome after brain injury: a multicenter, retrospective cohort study | Canada Hyperbarics Skip to main content
Cohort Study Med Gas Res 2025

Hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity syndrome after brain injury: a multicenter, retrospective cohort study

Wang H, Li Y, Shen S, Li X, Li C, Li Y, et al. — Med Gas Res, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers compared 56 brain injury patients who received HBOT for paroxysmal sympathetic hyperactivity (PSH), a condition of uncontrolled nervous system surges, against 36 patients who did not receive HBOT, across five Chinese ICUs.

What They Found

After 3 courses of HBOT (twice daily, 70 minutes per session, 10 days per course), patients in the HBOT group had significantly higher Glasgow Coma Scale scores, lower PSH symptom scores, and shorter ICU stays than the control group. Symptoms of PSH, including fever, sweating, rapid heart rate, and muscle rigidity, were significantly reduced in HBOT patients.

What This Means for Canadian Patients

For Canadians recovering from traumatic brain injury or stroke in an ICU, PSH can extend recovery and worsen outcomes. This study suggests HBOT may shorten ICU stays and reduce the severity of these dangerous nervous system surges, potentially speeding the path to rehabilitation.

Canadian Relevance

No direct Canadian connection identified. Paroxysmal sympathetic hyperactivity after brain injury is not an OHIP-covered indication for HBOT in Ontario.

Study Limitations

This retrospective multi-center study had no randomization, meaning patients who received HBOT may have differed from controls in ways that influenced outcomes.

Was this summary helpful?

Study Details

Study Type Cohort Study
Category Neurological
Source Pubmed
PubMed ID 39829168
Year Published 2025
Journal Med Gas Res
MeSH Terms Adult; Female; Humans; Male; Middle Aged; Autonomic Nervous System Diseases; Brain Injuries; Hyperbaric Oxygenation; Retrospective Studies; Treatment Outcome

Cite This Study

Share
Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.