Hyperbaric Oxygen Therapy Improves Motor Symptoms, Sleep, and Cognitive Dysfunctions in Parkinson's Disease | Canada Hyperbarics Skip to main content
Meta-Analysis Dement Geriatr Cogn Disord 2025

Hyperbaric Oxygen Therapy Improves Motor Symptoms, Sleep, and Cognitive Dysfunctions in Parkinson's Disease

Bu S, Liu W, Sheng X, Jin L, Zhao Q — Dement Geriatr Cogn Disord, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers pooled data from 13 studies involving 958 Parkinson's disease patients to compare hyperbaric oxygen therapy (HBOT) against standard drug treatment for motor and non-motor symptoms.

What They Found

Patients who received HBOT were 3.18 times more likely to show treatment success than those on standard drugs alone (95% CI: 1.60–6.33). Motor function scores on the UPDRS III improved significantly (mean difference of -2.96 points), and cognitive scores on the MoCA improved by a standardised mean difference of 0.65. Sleep quality also improved markedly, with Pittsburgh Sleep Quality Index scores dropping by an average of 2.52 points.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

Most included studies came from Chinese databases and had variable HBOT protocols, making it difficult to determine the ideal pressure, session length, or frequency for Parkinson's patients.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Meta-Analysis
Category Neurological
Source Pubmed
PubMed ID 39571556
Year Published 2025
Journal Dement Geriatr Cogn Disord
MeSH Terms Humans; Parkinson Disease; Hyperbaric Oxygenation; Cognitive Dysfunction; Sleep Wake Disorders; Treatment Outcome; Sleep Quality

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology