Clinical Study The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2018

Hyperbaric oxygen therapy increases the risk of tuberculosis disease.

Wang KY, Lin YS, Sy CL, Huang WC, Chen LW — The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2018

View Original on PubMed PMID 29862947

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a matched cohort study using a national health insurance database to compare the incidence of tuberculosis reactivation in patients who underwent hyperbaric oxygen therapy versus a matched control group.

What They Found

Out of 2258 patients, 1129 received hyperbaric oxygen therapy (HBOT) and 1129 did not. One year post-exposure, the HBOT group had significantly more active tuberculosis cases (11 cases) compared to the non-HBOT group (1 case, P = 0.006). Multiple regression analysis confirmed HBOT as the sole significant contributor to TB activation.

Canadian Relevance

This study has no direct Canadian connection as it was conducted using a national health insurance database from another country.

Study Limitations

As a retrospective database study, it may be limited by unmeasured confounding factors or specific characteristics of the studied population.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	29862947
Year Published	2018
Journal	The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
MeSH Terms	Databases, Factual; Disease Progression; Female; Humans; Hyperbaric Oxygenation; Incidence; Interferon-gamma Release Tests; Latent Tuberculosis; Male; Middle Aged; Mycobacterium tuberculosis; Regression Analysis; Retrospective Studies; Risk Factors; Tuberculin Test

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology