Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: prospective, randomized clinical trial | Canada Hyperbarics Skip to main content
RCT Sci Rep 2024

Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: prospective, randomized clinical trial

Boussi-Gross R, Catalogna M, Lang E, Shamai Z, Ablin J, Aloush V, et al. — Sci Rep, 2024

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers randomly assigned 48 fibromyalgia patients, all with a history of childhood sexual abuse, to either 60 HBOT sessions at 2 ATA for 90 minutes or standard drug therapy (pregabalin and duloxetine) to compare which worked better.

What They Found

HBOT produced significantly greater improvement in fibromyalgia symptoms than the medications, with a large effect size (Cohen's d = -1.27, p < 0.001). HBOT patients also showed better emotional wellbeing and daily function. Brain scans confirmed increased activity in the prefrontal and temporal regions, suggesting HBOT physically changed how the brain processed pain.

What This Means for Canadian Patients

Fibromyalgia affects an estimated 1.5 million Canadians and is particularly hard to treat when linked to trauma. This trial offers hope that HBOT may be a more effective option than current medications for people with trauma-related fibromyalgia.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The study was not blinded (patients knew which treatment they received), which could have influenced self-reported outcomes.

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Study Details

Study Type RCT
Category Neurological
Source Pubmed
PubMed ID 38773296
Year Published 2024
Journal Sci Rep
MeSH Terms Humans; Fibromyalgia; Hyperbaric Oxygenation; Female; Male; Adult; Middle Aged; Child Abuse, Sexual; Prospective Studies; Duloxetine Hydrochloride; Pregabalin; Treatment Outcome; Surveys and Questionnaires; Tomography, Emission-Computed, Single-Photon; Analgesics

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.