Hyperbaric Oxygen Therapy with Iloprost Improves Digit Salvage in Severe Frostbite Compared to Iloprost Alone | Canada Hyperbarics Skip to main content
Study Medicina (Kaunas) 2021

Hyperbaric Oxygen Therapy with Iloprost Improves Digit Salvage in Severe Frostbite Compared to Iloprost Alone

Magnan M, Gayet-Ageron A, Louge P, Champly F, Joffre T, Lovis C, et al. — Medicina (Kaunas), 2021

View Original on PubMed PMID 34833502
Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a multicenter prospective study comparing hyperbaric oxygen therapy plus iloprost to a historical cohort receiving iloprost alone for severe frostbite.

What They Found

The prospective cohort (28 patients) receiving HBO plus iloprost had a significantly higher mean number of preserved segments per patient (13 ± 10) compared to the historical cohort (30 patients) receiving iloprost alone (6 ± 5, p = 0.006). The odds of preserving segments were 45-fold higher (95%CI: 6-335, p < 0.001) in the HBO plus iloprost group.

Canadian Relevance

This study has no direct Canadian connection as it was conducted in a cross-border program among hyperbaric centers in Geneva, Lyon, and Mont-Blanc hospitals.

Study Limitations

A significant limitation is the comparison to a historical cohort rather than a concurrently randomised control group, which introduces potential biases.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Study
Category Neurological
Source Pubmed
PubMed ID 34833502
Year Published 2021
Journal Medicina (Kaunas)
MeSH Terms Fibrinolytic Agents; Frostbite; Humans; Hyperbaric Oxygenation; Iloprost; Prospective Studies

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology