Hyperbaric Oxygen Treatment for Long-COVID syndrome: A Systematic Review of Current Evidence on Cognitive Decline | Canada Hyperbarics Skip to main content
Systematic Review Undersea Hyperb Med 2025

Hyperbaric Oxygen Treatment for Long-COVID syndrome: A Systematic Review of Current Evidence on Cognitive Decline

Zamora F, Santos A, Zamora A, Galvao L, Pimenta N, Salles J, et al. — Undersea Hyperb Med, 2025

Tier 1, Curated

Manually reviewed and included in the Canada Hyperbarics research database.

Summary

What Researchers Did

Researchers conducted a systematic review of 7 studies involving 199 patients to evaluate whether HBOT improves thinking, memory, and fatigue in people with long COVID.

What They Found

Across the studies, HBOT at 2.0–2.5 ATA for 10 to 60 sessions improved memory, attention, executive function, fatigue, and pain in long COVID patients. Side effects were minimal and none were serious. Both randomized controlled trials and observational studies showed benefit.

What This Means for Canadian Patients

For Canadians living with long COVID brain fog, fatigue, and cognitive decline, a group estimated in the hundreds of thousands nationally, HBOT may offer meaningful symptom relief where no approved drug treatment currently exists. Sessions at 2.0–2.5 ATA appear safe for this population.

Canadian Relevance

No direct Canadian connection identified. Long COVID is not currently an OHIP-covered HBOT indication.

Study Limitations

The review included only 199 patients across 7 studies, making it too small to draw firm conclusions, and study protocols varied widely in pressure, session count, and outcome measures.

Was this summary helpful?

Study Details

Study Type Systematic Review
Category Neurological
Source Pubmed
PubMed ID 41223394
Year Published 2025
Journal Undersea Hyperb Med
MeSH Terms Humans; Hyperbaric Oxygenation; Cognitive Dysfunction; COVID-19; Executive Function; Post-Acute COVID-19 Syndrome; Attention; Randomized Controlled Trials as Topic; Fatigue

Cite This Study

Share
Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.