Clinical Study Brain research 2002

Hyperbaric oxygenation prevented brain injury induced by hypoxia-ischemia in a neonatal rat model.

Calvert JW, Yin W, Patel M, Badr A, Mychaskiw G, Parent AD, et al. — Brain research, 2002

View Original on PubMed PMID 12231450

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This study investigated whether hyperbaric oxygen (HBO) treatment could protect against brain injury induced by hypoxia-ischaemia (HI) in a neonatal rat model.

What They Found

After hypoxia-ischaemia, the ipsilateral hemisphere in untreated rats was 52.65% and 57.64% of the contralateral hemisphere at 2 and 6 weeks, respectively (P<0.001). In contrast, HBO-treated rats showed significantly less brain atrophy, with ipsilateral hemispheres measuring 77.77% and 84.19% at 2 and 6 weeks (P<0.001), along with improved sensorimotor function.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada, nor did it involve Canadian researchers or patients.

Study Limitations

A primary limitation of this study is its reliance on a neonatal rat model, meaning the findings may not directly translate to human infants.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	12231450
Year Published	2002
Journal	Brain research
MeSH Terms	Animals; Animals, Newborn; Asphyxia Neonatorum; Body Weight; Brain; Cerebral Infarction; Dentate Gyrus; Disease Models, Animal; Female; Humans; Hyperbaric Oxygenation; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Microscopy, Electron

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology