RCT Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2005

Improvement in motor and cognitive impairment after hyperbaric oxygen therapy in a selected group of patients with cerebrovascular disease: a prospective single-blind controlled trial.

Vila JF, Balcarce PE, Abiusi GR, Dominguez RO, Pisarello JB — Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 2005

View Original on PubMed PMID 16457083

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a prospective, single-blind controlled trial to evaluate the effect of hyperbaric oxygen therapy on motor and cognitive function in 26 patients with cerebrovascular disease, frontal leukoaraiosis, and lacunar infarcts.

What They Found

The hyperbaric oxygen group (n=18) showed statistically significant improvement in all motor and cognitive function scales compared to the control group (n=8) (p<0.05). This neurological improvement persisted in the majority of patients for up to 6 months, and symptoms improved again upon retreatment in 9 patients.

Canadian Relevance

This study has no direct Canadian connection as it was not conducted in Canada, nor does it involve Canadian researchers or patients.

Study Limitations

The study was limited by its small sample size and the fact that investigators were not blinded to the treatment groups.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

Was this summary helpful?

Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	16457083
Year Published	2005
Journal	Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
MeSH Terms	Aged; Basal Ganglia Diseases; Cerebral Infarction; Cerebrovascular Disorders; Cognition Disorders; Female; Gait Disorders, Neurologic; Humans; Hyperbaric Oxygenation; Leukoaraiosis; Male; Middle Aged; Oxygen; Prospective Studies; Single-Blind Method

Related Research

PLoS ONE | 2013 RCT

Hyperbaric oxygen induces late neuroplasticity in post stroke patients--randomized, prospective trial.

Efrati S, Fishlev G, Bechor Y, et al.

J Neurotrauma | 2018 Systematic Review

Hyperbaric oxygen therapy in the treatment of acute severe traumatic brain injury: a systematic review

Daly S, Thorpe M, Rockswold S, et al.

J Neurotrauma | 2012 Pilot Study

A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and PTSD

Harch PG, Andrews SR, Fogarty EF, et al.

Scientific Reports | 2022 RCT

Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.

Hadanny A, Zilberman-Itskovich S, Catalogna M, et al.

PLoS ONE | 2013 RCT

Hyperbaric oxygen therapy can improve post concussion syndrome years after mild traumatic brain injury — randomized prospective trial

Boussi-Gross R, Golan H, Fishlev G, et al.

See all Neurological research

View on PubMed Back to Research Library

Discuss with a qualified healthcare professional. Then: Review Coverage Guide View Recognised Conditions

Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology