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Review Curr Drug Targets 2013

Inhalation gases or gaseous mediators as neuroprotectants for cerebral ischaemia

Sutherland B, Harrison J, Nair S, Sammut I — Curr Drug Targets, 2013

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

This review explored the potential of therapeutic gases and gaseous mediators to protect the brain from damage after an ischemic stroke.

What They Found

The review found that various gases, including hyperbaric and normobaric oxygen, xenon, hydrogen, helium, and argon, have shown neuroprotective effects in preclinical models of ischemic stroke. Modulating cellular gaseous mediators like nitric oxide, carbon monoxide, and hydrogen sulphide also presents a promising strategy for protecting the brain from stroke damage.

What This Means for Canadian Patients

For Canadian patients experiencing ischemic stroke, this review suggests that therapeutic gases, including hyperbaric oxygen, could offer new ways to protect the brain from damage. While these therapies are still in early stages, they represent potential future treatments to improve outcomes for stroke survivors.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The review primarily discusses preclinical evidence, and the translation of these promising gas therapies into successful clinical treatments for human stroke patients is still unconfirmed.

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Study Details

Study Type Review
Category Neurological
Source Pubmed
PubMed ID 23170797
Year Published 2013
Journal Curr Drug Targets
MeSH Terms Administration, Inhalation; Animals; Brain Ischemia; Carbon Monoxide; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Hydrogen; Hydrogen Sulfide; Hyperbaric Oxygenation; Neuroprotective Agents; Nitric Oxide; Noble Gases; Treatment Outcome

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.