RCT Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc 2001

Lidocaine in the treatment of decompression illness: a review of the literature.

Mitchell SJ — Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc, 2001

View Original on PubMed PMID 12067153

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers conducted a review of the literature on lidocaine's use in treating decompression illness.

What They Found

The review found that lidocaine is neuroprotective in cerebral arterial gas embolism (CAGE) and various models of ischaemic brain injury. One randomised double-blind study showed improved neuropsychological outcomes in cardiac surgery patients receiving lidocaine, though clinical evidence for decompression illness (DCI) is limited to anecdotal reports.

Canadian Relevance

This study has no direct Canadian connection.

Study Limitations

The clinical evidence for lidocaine's efficacy in decompression illness is primarily limited to anecdotal reports and limited in vivo investigation.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type	RCT
Category	Neurological
Source	Pubmed
PubMed ID	12067153
Year Published	2001
Journal	Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc
MeSH Terms	Cell Hypoxia; Decompression Sickness; Energy Metabolism; Humans; Intracranial Embolism; Lidocaine; Neurons; Neuroprotective Agents

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology