What Researchers Did
Researchers reviewed current evidence on the mechanisms and therapeutic potential of hyperbaric oxygen therapy (HBO) in modulating autophagy in cerebral ischaemia-reperfusion injury (CIRI).
What They Found
They found that hyperbaric oxygen therapy (HBO) modulates autophagy through AMPK-mTOR, HIF-1α-mTOR, and PI3K-AKT pathways, playing a dual role in cell survival or injury. Preclinical studies demonstrate HBO upregulates LC3-II and Beclin-1 while downregulating p62, indicating enhanced autophagy, and clinical trials like OPENS-2 suggest synergistic effects with endovascular therapy.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
Limitations include the lack of standardised biomarkers and optimal treatment parameters for hyperbaric oxygen therapy, necessitating future large-scale randomised controlled trials.