Persistent post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies | Canada Hyperbarics Skip to main content
Review Expert Rev Neurother 2025

Persistent post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies

Hadanny A, Efrati S — Expert Rev Neurother, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed the latest science on why post-concussion symptoms last for months or years after a mild head injury, and examined emerging treatments including hyperbaric oxygen therapy (HBOT).

What They Found

Persistent post-concussion syndrome (PCS) involves measurable brain changes visible on advanced imaging, along with identifiable biological markers in the blood. Current standard treatments have limited success. Evidence reviewed suggests HBOT, along with neuromodulation and targeted therapies, may address the underlying brain damage rather than just masking symptoms.

What This Means for Canadian Patients

Hundreds of thousands of Canadians sustain concussions each year, and up to 30% develop persistent symptoms that affect work, school, and daily life. This review supports a shift toward personalized treatment plans that combine HBOT with other therapies for people whose symptoms do not improve after standard care.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This is a review article, not a clinical trial, so it summarizes existing evidence rather than producing new patient outcome data.

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Study Details

Study Type Review
Category Neurological
Source Pubmed
PubMed ID 40481820
Year Published 2025
Journal Expert Rev Neurother
MeSH Terms Humans; Post-Concussion Syndrome; Neuroimaging; Biomarkers; Brain Concussion; Hyperbaric Oxygenation; Quality of Life

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.