Persistent post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies | Canada Hyperbarics Skip to main content
Review Expert Rev Neurother 2025

Persistent post-concussion syndrome: pathophysiology, diagnosis, current and evolving treatment strategies

Hadanny A, Efrati S — Expert Rev Neurother, 2025

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers reviewed the latest science on why post-concussion symptoms last for months or years after a mild head injury, and examined emerging treatments including hyperbaric oxygen therapy (HBOT).

What They Found

Persistent post-concussion syndrome (PCS) involves measurable brain changes visible on advanced imaging, along with identifiable biological markers in the blood. Current standard treatments have limited success. Evidence reviewed suggests HBOT, along with neuromodulation and targeted therapies, may address the underlying brain damage rather than just masking symptoms.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

This is a review article, not a clinical trial, so it summarizes existing evidence rather than producing new patient outcome data.

This plain-language summary is generated with AI assistance and checked against the source abstract before publication. See our editorial policy.

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Study Details

Study Type Review
Category Neurological
Source Pubmed
PubMed ID 40481820
Year Published 2025
Journal Expert Rev Neurother
MeSH Terms Humans; Post-Concussion Syndrome; Neuroimaging; Biomarkers; Brain Concussion; Hyperbaric Oxygenation; Quality of Life

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology