Clinical Trial Cell Transplant 2019

Protective Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Patients with Vascular Dementia

Xu Y, Wang Q, Qu Z, Yang J, Zhang X, Zhao Y — Cell Transplant, 2019

View Original on PubMed PMID 31134827

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers ran a clinical trial with 158 patients with vascular dementia, randomised to receive conventional treatment alone or conventional treatment plus HBOT at 2 ATA for 60 minutes, 5 days per week for 12 weeks.

What They Found

After treatment, MMSE cognitive scores were significantly higher in the HBOT group compared to controls (p < 0.05). Serum levels of Humanin (a neuroprotective mitochondrial peptide) were also significantly higher in the HBOT group and positively correlated with cognitive improvement.

Canadian Relevance

No direct Canadian connection identified.

Study Limitations

The trial was conducted in China with a single ethnic population; the 12-week treatment period may not reflect long-term benefit, and blinding details are not reported.

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Study Details

Study Type	Clinical Trial
Category	Neurological
Source	Pubmed
PubMed ID	31134827
Year Published	2019
Journal	Cell Transplant
MeSH Terms	Aged; Cognition; Dementia, Vascular; Female; Humans; Hyperbaric Oxygenation; Intracellular Signaling Peptides and Proteins; Logistic Models; Male; Protective Agents; Statistics, Nonparametric

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Disclaimer: This study summary is provided for informational and educational purposes only. It does not constitute medical advice. The information presented reflects the findings of the original research authors and may not represent the views of Canada Hyperbarics. Always consult a qualified healthcare professional before making treatment decisions.

Last reviewed: March 19, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology