What Researchers Did
Researchers conducted a nonrandomized pilot trial to investigate if hyperbaric oxygen therapy (HBO2) could improve neurologic deficits and regional cerebral blood flow (rCBF) in five subjects with chronic traumatic brain injury (TBI).
What They Found
The study found no significant objective changes in neurologic function, neuropsychometric scores, exercise testing, MRIs, or regional cerebral blood flow (rCBF) in the five TBI subjects who received 120 HBO2 treatments. Compared to five head-injured controls and five healthy controls, hyperbaric oxygen therapy did not lead to clinical or rCBF improvement in the TBI group.
Canadian Relevance
This study has no direct Canadian connection.
Study Limitations
A primary limitation of this study is its small sample size and nonrandomized pilot design, which limits the generalizability of the findings.