Rhino-cerebral fungal infection successfully treated with supplementary hyperbaric oxygen therapy.

What Researchers Did

Researchers reported on a case of a woman with a rhino-cerebral fungal infection that was successfully treated with supplementary hyperbaric oxygen therapy after initial antifungal treatment failed.

What They Found

A woman presented with left trigeminal neuralgia, ophthalmoplegia, and blindness, with MRI revealing a lesion of the left orbital apex and cavernous sinus. Biopsy confirmed fungal infiltration (aspergillosis or mucormycosis), and after six weeks of high-dose liposomal Amphotericin B (5mg/kg/day) proved unsuccessful, supplementary hyperbaric oxygen therapy led to clinical and radiological improvement.

Canadian Relevance

This study has no direct Canadian connection as it was conducted outside of Canada.

Study Limitations

The primary limitation of this study is its design as a single case report, which limits the generalizability of its findings to a broader patient population.