What Researchers Did
Researchers conducted a systematic review of 44 human and animal studies to assess the interaction between medication and hyperbaric conditions, aiming to guide fitness-to-dive decisions for medicated divers.
What They Found
Animal studies revealed that diazepam and valproate offered limited protection against high-pressure neurological syndrome, while lithium protected against nitrogen-narcosis and losartan reduced cardiac changes in repetitive diving. Human studies found no beneficial or dangerous pressure-related interactions, though pseudoephedrine reduced otic barotrauma and vitamins C and E mitigated endothelial dysfunction and oxidative stress.
Canadian Relevance
This systematic review did not include any studies specifically conducted in Canada or involving Canadian populations. However, its findings on medication and hyperbaric conditions are globally relevant to divers, including those in Canada.
Study Limitations
A key limitation is the scarcity of human studies demonstrating clear beneficial or dangerous pressure-related interactions with medication, relying heavily on animal data for some findings.