Clinical Study No to shinkei = Brain and nerve 1986

The effect of hyperoxemia on cerebral blood flow in normal humans.

Ohta H — No to shinkei = Brain and nerve, 1986

View Original on PubMed PMID 3098265

Tier 2, Indexed

Automatically imported from PubMed based on relevance criteria.

Summary

What Researchers Did

Researchers investigated the impact of various degrees of hyperoxemia, including hyperbaric oxygenation, on cerebral blood flow (CBF) in 28 healthy volunteers.

What They Found

Cerebral blood flow (CBF) decreased significantly with increasing hyperoxemia, dropping from 100% at rest to 79% at 1 ATA.O2 (PaO2: 432 mmHg) and 71% at 2 ATA.O2 (PaO2: 838 mmHg). While CBF showed a slight increase to 81% at 2.5 ATA.O2 (PaO2: 1103 mmHg), all hyperoxemia conditions resulted in statistically significant CBF reductions compared to resting levels.

Canadian Relevance

This study has no direct Canadian connection as it was conducted in Japan.

Study Limitations

The study was conducted on a relatively small group of 28 healthy volunteers, which may limit the generalizability of these findings to diverse patient populations.

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Study Details

Study Type	Clinical Study
Category	Neurological
Source	Pubmed
PubMed ID	3098265
Year Published	1986
Journal	No to shinkei = Brain and nerve
MeSH Terms	Administration, Inhalation; Adult; Carbon Dioxide; Cerebrovascular Circulation; Female; Humans; Hyperbaric Oxygenation; Male; Middle Aged; Oxygen

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Last reviewed: April 2, 2026 | Reviewed by: Canada Hyperbarics Editorial Team | Editorial process | Research sources | Counts & methodology